- S1.E1 ∙ George Takei
- S1.E2 ∙ Christopher Nolan
- S1.E3 ∙ Dan Savage
- S1.E4 ∙ Arianna Huffington
- S1.E5 ∙ Richard Dawkins
- S1.E6 ∙ Jimmy Carter
- S1.E7 ∙ Chris Hadfield
- S1.E8 ∙ Biz Stone
- S1.E9 ∙ Charles Bolden
- S1.E10 ∙ Norman Lear
- S2.E1 ∙ Bill Clinton
- S2.E2 ∙ Larry Wilmore
- S2.E3 ∙ Seth MacFarlane
- S2.E4 ∙ Penn and Teller
- S2.E5 ∙ Susan Sarandon
- S2.E6 ∙ David Byrne
- S2.E7 ∙ Mars 1
- S2.E8 ∙ David Crosby
- S2.E9 ∙ Brian Cox
- S2.E10 ∙ Gina McCarthy
- S3.E1 ∙ Whoopi Goldberg
- S3.E2 ∙ Mayim Bialik
- S3.E3 ∙ Man on Wire
- S3.E4 ∙ Time Travel
- S3.E5 ∙ Theoretical Physics
- S3.E6 ∙ Robert Kirkman and the Walking Dead
- S3.E7 ∙ Jeremy Irons
- S3.E8 ∙ The Martian
- S3.E9 ∙ Ben Stiller
- S3.E10 ∙ Buzz Aldrin
- S3.E11 ∙ Terry Crews
- S3.E12 ∙ Jay Leno
- S3.E13 ∙ William Shatner
- S3.E14 ∙ US Secretary of Defense Ash Carter
- S3.E15 ∙ Hope Solo
- S3.E16 ∙ Search for Aliens
- S3.E17 ∙ The Science of Weather
- S3.E18 ∙ Science of Game of Thrones
- S3.E19 ∙ Herbie Hancock and Wayne Shorter
- S3.E20 ∙ Bill Maher
- S4.E1 ∙ Lance Armstrong
- S4.E2 ∙ Kareem Abdul-Jabbar
- S4.E3 ∙ Jane Goodall
- S4.E4 ∙ Katie Couric
- S4.E5 ∙ Kevin Smith
- S4.E6 ∙ SciFi Meets National Defense
- S4.E7 ∙ Katy Perry
- S4.E8 ∙ Sylvia Earle, Fabien Cousteau & Adrian Grenier
- S4.E9 ∙ James Cameron
- S4.E10 ∙ Celestial Navigation
- S4.E11 ∙ Salman Rushdie
- S4.E12 ∙ Interstellar Space Travel
- S4.E13 ∙ Alan Alda
- S4.E14 ∙ Stephen Colbert
- S4.E15 ∙ True Story of Hidden Figures
- S4.E16 ∙ Sam Harris and the Science of Belief
- S4.E17 ∙ Frank Oz and the Science of Puppeteering
- S4.E18 ∙ Kelly Slater and the Science of Surfing
- S4.E19 ∙ Astronaut Scott Kelly
- S4.E20 ∙ Stephen Hawking
- S5.E1 ∙ Anthony Bourdain
- S5.E2 ∙ Joe Rogan and the Science of Primitive Man
- S5.E3 ∙ The Big Bang Theory's Simon Helberg & Bill Prady
- S5.E4 ∙ US Space Command
- S5.E5 ∙ Vice President Al Gore
- S5.E6 ∙ Actor Jack Black
- S5.E7 ∙ News Anchor Dan Rather
- S5.E8 ∙ Author George R.R. Martin
- S5.E9 ∙ Actress Anna Deavere Smith
- S5.E10 ∙ Actor Jeff Goldblum
- S5.E11 ∙ Actor James Marsden
- S5.E12 ∙ Weird Al Yankovic
- S5.E13 ∙ Author Patricia Cornwell
- S5.E14 ∙ Director Darren Aronofsky
- S5.E15 ∙ Bill Nye
- S5.E16 ∙ Journalist Christiane Amanpour

StarTalk (2015)
Famed astrophysicist Dr. Neil deGrasse Tyson discusses science and pop culture with notable guests.
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